Little Mosque on the Prairie met en scène une communauté musulmane qui cherche à avoir leur lieu de culte, dans une ville Canadienne, majoritairement Chrétienne.

Leo discovers three teen super-humans Adam, Bree and Chase, living in a secret underground lab in the high-tech home he shares with his inventor stepdad, Donald Davenport, his mom, Tasha, and Eddy, the "smart house" computer. Leo takes the trio to school, but when they are unable to contain their bionic abilities on campus, Davenport sends them away to a remote secret lab and now Leo must find a way to save his new friends.